Final Results of the Telaprevir Access Program: FibroScan Values Predict Safety and Efficacy in Hepatitis C Patients with Advanced Fibrosis or Cirrhosis
Identifieur interne : 002D97 ( Main/Exploration ); précédent : 002D96; suivant : 002D98Final Results of the Telaprevir Access Program: FibroScan Values Predict Safety and Efficacy in Hepatitis C Patients with Advanced Fibrosis or Cirrhosis
Auteurs : Antonia Lepida [Belgique] ; Massimo Colombo [Italie] ; Inmaculada Fernandez [Espagne] ; Djamal Abdurakhmanov [Russie] ; Paulo Abrao Ferreira [Brésil] ; Simone I. Strasser [Australie] ; Petr Urbanek [République tchèque] ; Alessandra Mangia [Italie] ; José L. Calleja [Espagne] ; Wafae Iraqi [France] ; Ralph Demasi [États-Unis] ; Isabelle Lonjon-Domanec [France] ; Christophe Moreno [Belgique] ; Heiner Wedemeyer [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- Accessibilité des services de santé, Adulte, Adulte d'âge moyen, Analyse de l'intention de traiter, Analyse multivariée, Anémie (étiologie), Cirrhose du foie (), Cirrhose du foie (physiopathologie), Cirrhose du foie (traitement médicamenteux), Facteurs de risque, Femelle, Foie (), Foie (anatomopathologie), Foie (physiopathologie), Hepacivirus (), Hepacivirus (physiologie), Humains, Hépatite C (), Hépatite C (physiopathologie), Hépatite C (traitement médicamenteux), Hépatite C (virologie), Jeune adulte, Mâle, Oligopeptides (effets indésirables), Oligopeptides (pharmacologie), Oligopeptides (usage thérapeutique), Phénomènes biomécaniques (), Résultat thérapeutique, Sujet âgé.
- MESH :
- anatomopathologie : Foie.
- effets indésirables : Oligopeptides.
- pharmacologie : Oligopeptides.
- physiologie : Hepacivirus.
- physiopathologie : Cirrhose du foie, Foie, Hépatite C.
- traitement médicamenteux : Cirrhose du foie, Hépatite C.
- usage thérapeutique : Oligopeptides.
- virologie : Hépatite C.
- étiologie : Anémie.
- Accessibilité des services de santé, Adulte, Adulte d'âge moyen, Analyse de l'intention de traiter, Analyse multivariée, Cirrhose du foie, Facteurs de risque, Femelle, Foie, Hepacivirus, Humains, Hépatite C, Jeune adulte, Mâle, Phénomènes biomécaniques, Résultat thérapeutique, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Anemia (etiology), Biomechanical Phenomena (drug effects), Female, Health Services Accessibility, Hepacivirus (drug effects), Hepacivirus (physiology), Hepatitis C (complications), Hepatitis C (drug therapy), Hepatitis C (physiopathology), Hepatitis C (virology), Humans, Intention to Treat Analysis, Liver (drug effects), Liver (pathology), Liver (physiopathology), Liver Cirrhosis (complications), Liver Cirrhosis (drug therapy), Liver Cirrhosis (physiopathology), Male, Middle Aged, Multivariate Analysis, Oligopeptides (adverse effects), Oligopeptides (pharmacology), Oligopeptides (therapeutic use), Risk Factors, Treatment Outcome, Young Adult.
- MESH :
- chemical , adverse effects : Oligopeptides.
- complications : Hepatitis C, Liver Cirrhosis.
- drug effects : Biomechanical Phenomena, Hepacivirus, Liver.
- drug therapy : Hepatitis C, Liver Cirrhosis.
- etiology : Anemia.
- pathology : Liver.
- chemical , pharmacology : Oligopeptides.
- physiology : Hepacivirus.
- physiopathology : Hepatitis C, Liver, Liver Cirrhosis.
- chemical , therapeutic use : Oligopeptides.
- virology : Hepatitis C.
- Adult, Aged, Female, Health Services Accessibility, Humans, Intention to Treat Analysis, Male, Middle Aged, Multivariate Analysis, Risk Factors, Treatment Outcome, Young Adult.
Abstract
Liver stiffness determined by transient elastography is correlated with hepatic fibrosis stage and has high accuracy for detecting severe fibrosis and cirrhosis in chronic hepatitis C patients. We evaluated the clinical value of baseline FibroScan values for the prediction of safety and efficacy of telaprevir-based therapy in patients with advanced fibrosis and cirrhosis in the telaprevir Early Access Program HEP3002.
1,772 patients with HCV-1 and bridging fibrosis or cirrhosis were treated with telaprevir plus pegylated interferon-α and ribavirin (PR) for 12 weeks followed by PR alone, the total treatment duration depending on virological response and previous response type. Liver fibrosis stage was determined either by liver biopsy or by non-invasive markers. 1,282 patients (72%) had disease stage assessed by FibroScan; among those 46% were classified as Metavir F3 at baseline and 54% as F4.
Overall, 1,139 patients (64%) achieved a sustained virological response (SVR) by intention-to-treat analysis. Baseline FibroScan values were tested for association with SVR and the occurrence of adverse events. By univariate analysis, higher baseline FibroScan values were predictive of lower sustained virological response rates and treatment-related anemia. By multivariate analysis, FibroScan was no longer statistically significant as an independent predictor, but higher FibroScan values were correlated with the occurrence of infections and serious adverse events.
FibroScan has a limited utility as a predictor of safety and efficacy in patients treated with telaprevir-based triple therapy. Nevertheless it can be used in association with other clinical and biological parameters to help determine patients who will benefit from the triple regiments.
ClinicalTrials.gov
Url:
DOI: 10.1371/journal.pone.0138503
PubMed: 26398503
PubMed Central: 4580464
Affiliations:
- Allemagne, Australie, Belgique, Brésil, Espagne, France, Italie, Russie, République tchèque, États-Unis
- Basse-Saxe, Bohême centrale, Communauté de Madrid, District fédéral central, Lombardie, New Jersey, Nouvelle-Galles du Sud, Région de Bruxelles-Capitale, État de São Paulo, Île-de-France
- Bruxelles, Hanovre, Madrid, Milan, Moscou, Paris, Prague, Sydney, São Paulo
- Université de Sydney, Université de São Paulo
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Le document en format XML
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Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Colombo, Massimo" sort="Colombo, Massimo" uniqKey="Colombo M" first="Massimo" last="Colombo">Massimo Colombo</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medicine, Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Universita’ degli Studi di Milano, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medicine, Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Universita’ degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fernandez, Inmaculada" sort="Fernandez, Inmaculada" uniqKey="Fernandez I" first="Inmaculada" last="Fernandez">Inmaculada Fernandez</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Hospital Universitario 12 de Octubre, Sección de Aparato Digestivo, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario 12 de Octubre, Sección de Aparato Digestivo, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Abdurakhmanov, Djamal" sort="Abdurakhmanov, Djamal" uniqKey="Abdurakhmanov D" first="Djamal" last="Abdurakhmanov">Djamal Abdurakhmanov</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>I.M. Sechenov First Moscow State Medical University, E.M. Tareev Clinic for Nephrology, Internal and Occupational Medicine, Moscow, Russia</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>I.M. Sechenov First Moscow State Medical University, E.M. Tareev Clinic for Nephrology, Internal and Occupational Medicine, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Abrao Ferreira, Paulo" sort="Abrao Ferreira, Paulo" uniqKey="Abrao Ferreira P" first="Paulo" last="Abrao Ferreira">Paulo Abrao Ferreira</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Outpatient Clinic to HIV and Viral Hepatitis Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Outpatient Clinic to HIV and Viral Hepatitis Division of Infectious Disease, Federal University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Strasser, Simone I" sort="Strasser, Simone I" uniqKey="Strasser S" first="Simone I." last="Strasser">Simone I. Strasser</name><affiliation wicri:level="4"><nlm:aff id="aff006"><addr-line>AW Morrow Gastroenterology and Liver Center, Royal Prince Alfred hospital and University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>AW Morrow Gastroenterology and Liver Center, Royal Prince Alfred hospital and University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Urbanek, Petr" sort="Urbanek, Petr" uniqKey="Urbanek P" first="Petr" last="Urbanek">Petr Urbanek</name><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Department of Internal Medicine, First Medical Faculty, Charles University, and Central Military Hospital Prague, Prague, Czech Republic</addr-line></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Internal Medicine, First Medical Faculty, Charles University, and Central Military Hospital Prague, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Mangia, Alessandra" sort="Mangia, Alessandra" uniqKey="Mangia A" first="Alessandra" last="Mangia">Alessandra Mangia</name><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Liver Unit, IRCCS Hospital 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Liver Unit, IRCCS Hospital 'Casa Sollievo della Sofferenza', San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Calleja, Jose L" sort="Calleja, Jose L" uniqKey="Calleja J" first="José L." last="Calleja">José L. Calleja</name><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Gastroenterology, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, CIBERehd, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Gastroenterology, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, CIBERehd, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Iraqi, Wafae" sort="Iraqi, Wafae" uniqKey="Iraqi W" first="Wafae" last="Iraqi">Wafae Iraqi</name><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Janssen Pharmaceuticals, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Janssen Pharmaceuticals, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Demasi, Ralph" sort="Demasi, Ralph" uniqKey="Demasi R" first="Ralph" last="Demasi">Ralph Demasi</name><affiliation wicri:level="2"><nlm:aff id="aff011"><addr-line>Janssen Research and development, Titusville, New Jersey, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Janssen Research and development, Titusville, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Lonjon Domanec, Isabelle" sort="Lonjon Domanec, Isabelle" uniqKey="Lonjon Domanec I" first="Isabelle" last="Lonjon-Domanec">Isabelle Lonjon-Domanec</name><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Janssen Pharmaceuticals, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Janssen Pharmaceuticals, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moreno, Christophe" sort="Moreno, Christophe" uniqKey="Moreno C" first="Christophe" last="Moreno">Christophe Moreno</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Liver Unit, Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Liver Unit, Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Wedemeyer, Heiner" sort="Wedemeyer, Heiner" uniqKey="Wedemeyer H" first="Heiner" last="Wedemeyer">Heiner Wedemeyer</name><affiliation wicri:level="3"><nlm:aff id="aff012"><addr-line>Medizinische Hochschule Hannover, Hannover, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anemia (etiology)</term><term>Biomechanical Phenomena (drug effects)</term><term>Female</term><term>Health Services Accessibility</term><term>Hepacivirus (drug effects)</term><term>Hepacivirus (physiology)</term><term>Hepatitis C (complications)</term><term>Hepatitis C (drug therapy)</term><term>Hepatitis C (physiopathology)</term><term>Hepatitis C (virology)</term><term>Humans</term><term>Intention to Treat Analysis</term><term>Liver (drug effects)</term><term>Liver (pathology)</term><term>Liver (physiopathology)</term><term>Liver Cirrhosis (complications)</term><term>Liver Cirrhosis (drug therapy)</term><term>Liver Cirrhosis (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Oligopeptides (adverse effects)</term><term>Oligopeptides (pharmacology)</term><term>Oligopeptides (therapeutic use)</term><term>Risk Factors</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accessibilité des services de santé</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de l'intention de traiter</term><term>Analyse multivariée</term><term>Anémie (étiologie)</term><term>Cirrhose du foie ()</term><term>Cirrhose du foie (physiopathologie)</term><term>Cirrhose du foie (traitement médicamenteux)</term><term>Facteurs de risque</term><term>Femelle</term><term>Foie ()</term><term>Foie (anatomopathologie)</term><term>Foie (physiopathologie)</term><term>Hepacivirus ()</term><term>Hepacivirus (physiologie)</term><term>Humains</term><term>Hépatite C ()</term><term>Hépatite C (physiopathologie)</term><term>Hépatite C (traitement médicamenteux)</term><term>Hépatite C (virologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Oligopeptides (effets indésirables)</term><term>Oligopeptides (pharmacologie)</term><term>Oligopeptides (usage thérapeutique)</term><term>Phénomènes biomécaniques ()</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis C</term><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biomechanical Phenomena</term><term>Hepacivirus</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C</term><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anemia</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oligopeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Cirrhose du foie</term><term>Foie</term><term>Hépatite C</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hepatitis C</term><term>Liver</term><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Cirrhose du foie</term><term>Hépatite C</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Anémie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Health Services Accessibility</term><term>Humans</term><term>Intention to Treat Analysis</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Risk Factors</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Accessibilité des services de santé</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de l'intention de traiter</term><term>Analyse multivariée</term><term>Cirrhose du foie</term><term>Facteurs de risque</term><term>Femelle</term><term>Foie</term><term>Hepacivirus</term><term>Humains</term><term>Hépatite C</term><term>Jeune adulte</term><term>Mâle</term><term>Phénomènes biomécaniques</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Liver stiffness determined by transient elastography is correlated with hepatic fibrosis stage and has high accuracy for detecting severe fibrosis and cirrhosis in chronic hepatitis C patients. We evaluated the clinical value of baseline FibroScan values for the prediction of safety and efficacy of telaprevir-based therapy in patients with advanced fibrosis and cirrhosis in the telaprevir Early Access Program HEP3002.</p></sec><sec id="sec002"><title>Methods</title><p>1,772 patients with HCV-1 and bridging fibrosis or cirrhosis were treated with telaprevir plus pegylated interferon-α and ribavirin (PR) for 12 weeks followed by PR alone, the total treatment duration depending on virological response and previous response type. Liver fibrosis stage was determined either by liver biopsy or by non-invasive markers. 1,282 patients (72%) had disease stage assessed by FibroScan; among those 46% were classified as Metavir F3 at baseline and 54% as F4.</p></sec><sec id="sec003"><title>Results</title><p>Overall, 1,139 patients (64%) achieved a sustained virological response (SVR) by intention-to-treat analysis. Baseline FibroScan values were tested for association with SVR and the occurrence of adverse events. By univariate analysis, higher baseline FibroScan values were predictive of lower sustained virological response rates and treatment-related anemia. By multivariate analysis, FibroScan was no longer statistically significant as an independent predictor, but higher FibroScan values were correlated with the occurrence of infections and serious adverse events.</p></sec><sec id="sec004"><title>Conclusions</title><p>FibroScan has a limited utility as a predictor of safety and efficacy in patients treated with telaprevir-based triple therapy. Nevertheless it can be used in association with other clinical and biological parameters to help determine patients who will benefit from the triple regiments.</p></sec><sec id="sec005"><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT01508286?id=NCT01508286&rank=1">NCT01508286</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rosen, Hr" uniqKey="Rosen H">HR Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verna, Ec" uniqKey="Verna E">EC Verna</name></author><author><name sortKey="Brown, Rs" uniqKey="Brown R">RS Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, Tr" uniqKey="Morgan T">TR Morgan</name></author><author><name sortKey="Ghany, Mg" uniqKey="Ghany M">MG Ghany</name></author><author><name sortKey="Kim, Hy" uniqKey="Kim H">HY 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Merrouche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poynard, T" uniqKey="Poynard T">T Poynard</name></author><author><name sortKey="Ngo, Y" uniqKey="Ngo Y">Y Ngo</name></author><author><name sortKey="Perazzo, H" uniqKey="Perazzo H">H Perazzo</name></author><author><name sortKey="Munteanu, M" uniqKey="Munteanu M">M Munteanu</name></author><author><name sortKey="Lebray, P" uniqKey="Lebray P">P Lebray</name></author><author><name sortKey="Moussalli, J" uniqKey="Moussalli J">J Moussalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Bk" uniqKey="Kim B">BK Kim</name></author><author><name sortKey="Fung, J" uniqKey="Fung J">J Fung</name></author><author><name sortKey="Yuen, Mf" uniqKey="Yuen M">MF Yuen</name></author><author><name sortKey="Kim, Su" uniqKey="Kim S">SU Kim</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Espagne</li><li>France</li><li>Italie</li><li>Russie</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Bohême centrale</li><li>Communauté de Madrid</li><li>District fédéral central</li><li>Lombardie</li><li>New Jersey</li><li>Nouvelle-Galles du Sud</li><li>Région de Bruxelles-Capitale</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Hanovre</li><li>Madrid</li><li>Milan</li><li>Moscou</li><li>Paris</li><li>Prague</li><li>Sydney</li><li>São Paulo</li></settlement><orgName><li>Université de Sydney</li><li>Université de São Paulo</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Lepida, Antonia" sort="Lepida, Antonia" uniqKey="Lepida A" first="Antonia" last="Lepida">Antonia Lepida</name></region><name sortKey="Moreno, Christophe" sort="Moreno, Christophe" uniqKey="Moreno C" first="Christophe" last="Moreno">Christophe Moreno</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Colombo, Massimo" sort="Colombo, Massimo" uniqKey="Colombo M" first="Massimo" last="Colombo">Massimo Colombo</name></region><name sortKey="Mangia, Alessandra" sort="Mangia, Alessandra" uniqKey="Mangia A" first="Alessandra" last="Mangia">Alessandra Mangia</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Fernandez, Inmaculada" sort="Fernandez, Inmaculada" uniqKey="Fernandez I" first="Inmaculada" last="Fernandez">Inmaculada Fernandez</name></region><name sortKey="Calleja, Jose L" sort="Calleja, Jose L" uniqKey="Calleja J" first="José L." last="Calleja">José L. Calleja</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Abdurakhmanov, Djamal" sort="Abdurakhmanov, Djamal" uniqKey="Abdurakhmanov D" first="Djamal" last="Abdurakhmanov">Djamal Abdurakhmanov</name></region></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Abrao Ferreira, Paulo" sort="Abrao Ferreira, Paulo" uniqKey="Abrao Ferreira P" first="Paulo" last="Abrao Ferreira">Paulo Abrao Ferreira</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Strasser, Simone I" sort="Strasser, Simone I" uniqKey="Strasser S" first="Simone I." last="Strasser">Simone I. Strasser</name></region></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Urbanek, Petr" sort="Urbanek, Petr" uniqKey="Urbanek P" first="Petr" last="Urbanek">Petr Urbanek</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Iraqi, Wafae" sort="Iraqi, Wafae" uniqKey="Iraqi W" first="Wafae" last="Iraqi">Wafae Iraqi</name></region><name sortKey="Lonjon Domanec, Isabelle" sort="Lonjon Domanec, Isabelle" uniqKey="Lonjon Domanec I" first="Isabelle" last="Lonjon-Domanec">Isabelle Lonjon-Domanec</name></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Demasi, Ralph" sort="Demasi, Ralph" uniqKey="Demasi R" first="Ralph" last="Demasi">Ralph Demasi</name></region></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Wedemeyer, Heiner" sort="Wedemeyer, Heiner" uniqKey="Wedemeyer H" first="Heiner" last="Wedemeyer">Heiner Wedemeyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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